The structure of aminoglycoside antibiotic 66-40G produced by Micromonospora inyoensis.
نویسندگان
چکیده
Aminoglycoside antibiotic 66-40G is a minor component produced in the fermentation of Micromonospora inyoensis. Its structure has been established as 3''-de-N-methyl-sisomicin (4) by spectroscopic means and by direct comparison with an authentic sample obtained from photochemical oxidative de-N-methylation of sisomicin (1).
منابع مشابه
Cloning and characterization of the sisomicin-resistance gene from Micromonospora inyoensis.
We cloned DNA fragments of sisomicin-producing Micromonospora inyoensis into Streptomyces plasmid vectors and identified Streptomyces lividans TK24 transformants expressing the M. inyoensis sisomicin-resistance (sisA) gene. The sisA gene was compared to the previously reported Micromonospora purpurea Kan-Gen (kanamycin-gentamicin)-resistance gene. While the restriction endonuclease digestion pa...
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 31 7 شماره
صفحات -
تاریخ انتشار 1978